Detection of Telomerase Activity in Leukoplakia and Oral Submucous Fibrosis

Krishna R Kumar , Ani John


The enzyme telomerase, a ribonucleoprotein complex, adds telomeric repeats of TTAGGG at the end of chromosomes, thus playing a key role in maintaining telomeric length in germ cells and immortalized cancer cells. Activation of the telomerase enzyme is important for continuous cellular growth and its escape from cellular senescence. Telomerase activity is not detected in most normal somatic cells. It has however been demonstrated in most cancer cells. Relatively few studies have been carried out on oral precancerous lesions like Leukoplakia and oral submucous fibrosis. This study was aimed at detection of telomerase activity in Leukoplakia and oral submucous fibrosis.

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